Cathepsins mediate tumor metastasis

• 作者: Fa-Qing Tang Gong-Jun Tan Jin-Ping Lu Zheng-Ke Peng
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: CATHEPSIN TUMOR METASTASIS MECHANISM
• 年，卷（期）: 2013,（4）
• 页码范围: 91-101
• 页数: 11页
• 分类号: R730.2

摘要

Cathepsins are highly expressed in various human cancers, associated with tumor metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family members. As a group of lysosomal proteinases or endopeptidases, each member has a different function, playing different roles in distinct tumorigenic processes such as proliferation, angiogenesis, metastasis, and invasion. Cathepsins belong to a diverse number of enzyme subtypes, including cysteine proteases, serine proteases and aspartic proteases. The contribution of cathepsins to invasion in human cancers is well documented, although the precise mechanisms by which cathepsins exert their effects are still not clear. In the present review, the role of cathepsin family members in cancer is discussed.