New Developments in Drug Therapy and Research of Cerebral Vasospasm

• 作者: Eleftherios Archavlis Mario Carvi Y. Nievas Peter Ulrich
• 来源期刊: 现代神经外科学进展(英文)
• 学科: 医学
• 关键词: CEREBRAL VASOSPASM Drug Therapy SUBARACHNOID HEMORRHAGE Delayed CEREBRAL ISCHEMIA New DEVELOPMENTS Treatment
• 年，卷（期）: 2013,（4）
• 页码范围: 72-93
• 页数: 22页
• 分类号: R73

摘要

In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.