Polydopamine Particles Effect on Melanoma Cells Proliferation and Melanin Secretion

• 作者: Alice Ferrand Nadia Benkirane-Jessel Olivier Huck Sandy Eap Valérie Machi Vincent Ball
• 来源期刊: 化学工程与科学期刊(英文)
• 学科: 医学
• 关键词: POLYDOPAMINE PARTICLES POLYELECTROLYTE MULTILAYERS Films MELANIN MELANOMA Cells
• 年，卷（期）: 2013,（3）
• 页码范围: 1-10
• 页数: 10页
• 分类号: R73

摘要

Melanin is a biopolymer implicated in the protection of cellular membranes and DNA produced by melanocytes. This pigment has a dual role and should be considered as a photo-protector and as a photosensitizer due to its interaction with UV. The design of multifunctional and biologically responsive coatings is of major interest in modern biomaterials science. The aim of this study is not only to characterize the deposition of multilayered polyelectrolytes films made from polydopamine particles and polyamines like poly-(L-lysine hydrobromide) (PLL), but also to evaluate melanoma cells activity in terms of proliferation and their capacity to stimulate melanin secretion. One could expect that the presence of a melanin like material in the film may have a positive or a negative feedback on the melanin biosynthesis and consequently on melanoma development. Some comparisons are also done with pure polydopamine grains in suspension in the cell culture medium, to investigate if the immobilization of the polydopamine grains has an influence on their bioactivity.