Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering

• 作者: Carlos A. Martínez-Pérez Florinda Jiménez-Vega Imelda Olivas-Armendariz Mónica E. Mendoza-Duarte Perla García-Casillas Santos Adriana Martel-Estrada
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 工学
• 关键词: BONE TISSUE REGENERATION CHITOSAN Multiwalled Carbon NANOTUBES Composite
• 年，卷（期）: 2013,（2）
• 页码范围: 204-211
• 页数: 8页
• 分类号: TB3

摘要

In this work the influence of multiwalled carbon nanotubes (MWCNT) on mechanical properties was evaluated also the osteoinduction mechanism in Chitosan/MWCNT composite is reported. The morphology and the mechanical properties of the scaffolds were controlled by varying solvent ratios, quenching temperatures and carbon nanotubes concentration. In vitro cell culture of Sprague-Dawley rat’s osteoblasts was used to evaluate the phenotype expression of cells in the scaffolds. The presence of MWCNT in a chitosan matrix improving its mechanical properties and sustain osteoblast growth and differentiation that represent a potential application of the Chitosan/MWCNT as biomaterial for bone tissue engineering.