Improved Hemolytic Performance of Blood Pump with Fluorine-Doped Hydrogenated Amorphous Carbon Coating

• 作者: Akihiko Homma Akio Funakubo Hirohito Sumikura Kazuyoshi Fukunaga Kenji K. Hirakuri Masanori Hiratsuka Yasuharu Ohgoe Yasuhiro Fukui
• 来源期刊: 化学工程与科学期刊(英文)
• 学科: 医学
• 关键词: Fluorine-Doped a-C:H Film HEMOLYTIC PERFORMANCE Artificial Heart Blood PUMP
• 年，卷（期）: 2013,（3）
• 页码范围: 10-16
• 页数: 7页
• 分类号: R73

摘要

Fluorine-doped hydrogenated amorphous carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser surface (SUS 304) of an enclosed-impeller type flow blood pump using the ionization deposition method with a source gas of C6F5H. The surface characteristics of the a-C:H:F film were examined using atomic force microscopy, X-ray photoelectron spectroscopy, and measurements of surface roughness, friction and surface potential. The a-C:H:F film tends to increase surface roughness and the negative surface charge. In addition, the surface energy and friction decrease with fluorine dopant in the a-C:H film. To estimate the hemolytic performance of a blood pump with the a-C:H:F film coating, the amount of hemolysis was measured using a mock circulatory system (in vitro test) with 500 mL of pig blood containing sodium citrate. In vitro test was conducted for 180 min with the blood flow and pump head maintained at 5 L/min and 100 mmHg, respectively. The a-C:H:F film coating reduced the amount of hemolysis and improved the hemolytic performance. Decreasing the surface energy and negative surface charge of the a-C:H:F film contributes to the improvement of the hemolytic performance. The a-C:H:F film coating is thus expected to be utilized in medical technology as a surface coating technology for artificial heart blood pumps.