A novel mutation in <i>NF1</i>gene in a Chinese patient with Legius syndrome like caféau lait spots

• 作者: Dongdong Zheng Xiaohong Duan
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: Legius Syndrome NEUROFIBROMATOSIS Type I
• 年，卷（期）: 2013,（2）
• 页码范围: 141-142
• 页数: 2页
• 分类号: R73

摘要

Neurofibromatosis type I (NF1) (OMIM, 162200) and Legius syndrome (OMIM, 611431) both have multiple café au lait spots. It is a challenge to differentiate the two diseases. Here we report a Legius syndrome-like patient who finally was identified as NF1 with a novel mutation in NF1 exon1 (c.55G > T). The mutation caused a substitution of a glutamic acid (GAG) with a terminator codon (TAG). For those patients with only multiple café au lait macules, axillary and inguinal freckling, but without any other clinical signs in NF1 and Legius syndrome, a gene testing is necessary to give a final diagnose. We suggested to use “Neurofibromatosis type 1—like syndrome” to describe those patients just like our patient reported here.