Recyclable Cyclohexanediamine Derivatives as Organocatalysts: Organocatalytic Reduction with Trichlorosilane and Aldol Reaction

• 作者: Kaori Ishimaru Yuya Tanimura
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Aldol Reaction Cyclohexanediamine ORGANOCATALYSIS RECYCLABLE REDUCTION
• 年，卷（期）: 2013,（4）
• 页码范围: 240-242
• 页数: 3页
• 分类号: O6

摘要

Reduction of ketimine with trichlorosilane was carried out using bisformamide catalyst 1a derived from cyclohexanediamine to give the corresponding product in 81% yield with 39% ee. Deprotection of the formyl groups of the catalysts 1 gave the corresponding diamines 2 which were utilized in aldol reaction of acetone with 4-nitrobenzaldehyde. The reaction using 2b in brine afforded the aldol adduct in 81% yield with 29% ee.