Synthesis of Multifunctionalised 2-Substituted Benzimidazoles Using Copper (II) Hydroxide as Efficient Solid Catalyst

• 作者: Donthabakthuni Shobha Murugulla Adharvana Chari Sridhar Malayalama Zaied-A-Mosaa
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: O-PHENYLENEDIAMINE ALDEHYDES COPPER (II) HYDROXIDE Solid Catalyst Multifunctionalised BENZIMIDAZOLES
• 年，卷（期）: 2013,（4）
• 页码范围: 243-250
• 页数: 8页
• 分类号: O6

摘要

Here we demonstrate the synthesis of multifunctionalised benzimidazoles through the coupling of o-phenylenediamine with aldehydes by using Copper (II) hydroxide as an efficient solid catalyst in methanol at room temperature. The Copper (II) hydroxide solid catalyst gave better yields (80%-99%) in short reaction time (4-8 h). These commercially available cheap catalysts are more active than many reported expensive heterogeneous catalysts. Using the Copper hydroxide fresh catalyst, the yield of product 3a was 98%, while the recovered catalyst in the three subsequent cycles gave the yield of 94%, 90% and 88% respectively.