A high power buck-boost switch-mode LED driver delivering a constant 350 mA with a power efficient current sensing scheme is presented in this paper. The LED current is extracted by differentiating the output capacitor voltage and maintained by a feedback. The circuit has been fabricated in a standard 0.35 μm AMS CMOS process. Measurement results demonstrated a power-conversion efficiency over 90% with a line regulation of 8%/V for input voltage of 3.3 V and current output between 200 mA and 350 mA.