Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma

• 作者: Maher Alchreiki Mohammad Hussain Nicola Jabbour
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: OXALIPLATIN Peripheral Neuropathy NEUROMYOTONIA HYPEREXCITABILITY SYNDROME APPENDICEAL ADENOCARCINOMA Sodium Channels
• 年，卷（期）: 2013,（4）
• 页码范围: 236-238
• 页数: 3页
• 分类号: R73

摘要

Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome;a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.