Morphological abnormalities in <i>Drosophila</i>with overexpression of human APP gene

• 作者: Dmitry Rodin Galina Kislik Olga Bolshakova Svetlana Sarantseva
• 来源期刊: 动物科学期刊(英文)
• 学科: 医学
• 关键词: Alzheimer’s Disease DROSOPHILA Amyloid Precursor Protein MORPHOLOGICAL ABNORMALITIES
• 年，卷（期）: 2013,（4）
• 页码范围: 49-52
• 页数: 4页
• 分类号: R73

摘要

Alzheimer’s disease (AD) is the leading and one of the most severe forms of dementia. Molecular mechanisms underlying AD pathogenesis despite much work on this subject still remain unclear. Cleavage of amyloid precursor protein (APP) to amyloid beta peptide (A-beta) and following formation of amyloid plaques are the key events of Alzheimer’s pathology. Thus changes in APP expression and metabolism can lead to pathology development. Here we show that overexpression of human APP in Drosophila neural cells manifests in different morphological abnormalities of Drosophila imago that can be observed immediately after fly eclosion. This observation can help to further understand APP molecular functions and its participation in different molecular pathways.