Variant Map System to Simulate Complex Properties of DNA Interactions Using Binary Sequences

• 作者: Jeffrey Zheng Jin Luo Ruoyu Shen Wei Zhou Weiqiong Zhang
• 来源期刊: 理论数学进展(英文)
• 学科: 医学
• 关键词: PSEUDO-RANDOM Number Generator Stream CIPHER HC-256 Binary to DNA PSEUDO DNA Sequence Large Noncoding DNA Analysis 2D MAP Visual Distribution VARIANT MAP System
• 年，卷（期）: 2013,（7）
• 页码范围: 5-24
• 页数: 20页
• 分类号: R73

摘要

Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network security. From a random sequencing viewpoint, both sequences of HC-256 and real DNA data may have intrinsic pseudo-random properties respectively. In a recent decade, many DNA sequencing projects are developed on cells, plants and animals over the world into huge DNA databases. Researchers notice that mammalian genomes encode thousands of large noncoding RNAs (lncRNAs), interact with chromatin regulatory complexes, and are thought to play a role in localizing these complexes to target loci across the genome. It is a challenge target using higher dimensional visualization tools to organize various complex interactive properties as visual maps. The Variant Map System (VMS) as an emerging scheme is systematically proposed in this paper to apply multiple maps that used four Meta symbols as same as DNA or RNA representations. System architecture of key components and core mechanism on the VMS are described. Key modules, equations and their I/O parameters are discussed. Applying the VM System, two sets of real DNA sequences from both sample human (noncoding DNA) and corn (coding DNA) genomes are collected in comparison with pseudo DNA sequences generated by HC-256 to show their intrinsic properties in higher levels of similar relationships among relevant DNA sequences on 2D maps. Sample 2D maps are listed and their characteristics are illustrated under controllable environment. Visual results are briefly analyzed to explore their intrinsic properties on selected genome sequences.