Dynamic ¹⁸F-fluorodeoxyglucose positron emission tomography/CT in hibernoma: enhanced tracer uptake mimicking liposarcoma

• 作者: Antonia Dimitrakopoulou-Strauss Christos Sachpekidis Matthias Schwarzbach Safwan Roumia
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Hibernoma DYNAMIC POSITRON emission tomography/CT 18F-FLUORODEOXYGLUCOSE Kinetic Modeling Parametric imaging
• 年，卷（期）: 2013,（12）
• 页码范围: 498-502
• 页数: 5页
• 分类号: R730.4

摘要

We report on two cases of patients with fat-equivalent masses in computed tomography(CT),referred to our department for dynamic positron emission tomography/CT(dPET/CT)with18F-fluorodeoxyglucose(18FFDG)in order to investigate their dignity.Both qualitative and quantitative information,as derived from dPET/CTs,couldn’t exclude a high-grade liposarcoma:Visual evaluation,revealed a large hypermetabolic focus of intense18F-FDG uptake in each patient(average SUVs 8.3 and 11.3).Regression-based parametric imaging demonstrated an enhanced distribution volume,which correlates to perfusion,and a high phosphorylation rate that correlates to cell viability.Kinetic analysis,based on a two-tissue compartment model demonstrated an enhanced FDG transport k1and an enhanced phosphorylation rate k3.A non-compartmental approach based on fractal dimension revealed also enhanced values.However,final diagnosis was based on biopsy,which revealed hibernoma,a benign brown fat tumor.Brown adipose contains increased numbers of mitochondria and a high-rate of glucose metabolism.Therefore,they have increased FDG uptake.The evaluation of lipomatous lesions on CT,with high FDG uptake,should include the possibility of hibernoma as a differential diagnosis.