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Melatonin (MEL) was investigated for protection against the anthracycline antibiotic doxorubicin (Dox) that is well known for its oxidative damage to various body organs. It was aimed to have a comparison of this protection to heart, liver and kidney in the treated subjects. In this study, groups of mice were treated with Dox and melatonin and their individual or combined effects were evaluated by assessing lipidperoxidation, non-protein sulfhydryls (NP-SH) and nitrate/nitrite (NO) contents in these tissues. Plasma aminotransferases, LDH and CK-MB enzyme activities were measured. Moreover, these tissues were subject to histopathological assessment. MEL co-treatment significantly prevented any rise in lipidperoxides more significantly in heart and liver as compared to kidney. In tandem, MEL prevented a decline in GSH that was observed by Dox alone in liver and kidney. Dox significantly increased total NO levels in all the tissues. Melatonin at both dose levels could not afford protection against nitrosative stress. MEL in combination treatment provided significant (P
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篇名 Comparative Assessment of Melatonin-Afforded Protection in Liver, Kidney and Heart of Male Mice against Doxorubicin Induced Toxicity
来源期刊 药理与制药(英文) 学科 医学
关键词 MELATONIN DOXORUBICIN HEART LIVER KIDNEY Lipidperoxidation Non-Protein Sulfhydryls Nitric Oxide Plasma Enzymes Mice
年,卷(期) ylyzyyw_2013,(8) 所属期刊栏目
研究方向 页码范围 590-598
页数 9页 分类号 R73
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研究主题发展历程
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MELATONIN
DOXORUBICIN
HEART
LIVER
KIDNEY
Lipidperoxidation
Non-Protein
Sulfhydryls
Nitric
Oxide
Plasma
Enzymes
Mice
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研究去脉
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期刊影响力
药理与制药(英文)
月刊
2157-9423
武汉市江夏区汤逊湖北路38号光谷总部空间
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444
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0
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