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摘要:
Protective effect of catalpol on myocardium was studied in relation to endothelial progenitor cells, Notch1 signaling pathway and angiogenesis in rats with isoprenaline (INN)-induced acute myocardial infarcts. To analyze the pathological status and impact of catalpol on the rats, 3 weeks after intragastric gavage, the animals were verified for myocardial infarcts with electrocardiogram and measured for enzyme activity of lactate dehydrogenase (LDH), malondialdehyde (MDA), creatine kinase (CK) and superoxide dismutase (SOD) in myocardium, and further analyzed using HE and TTC staining, as well as visual examination of infarct area. Flow cytometry study of endothelial progenitor cells (EPCs) indicated that the EPCs were mobilized during infarction. The roles of Notch1 signaling pathway in angiogenesis of the infracted animals were studied using immunohistochemistry analysis of RBPjκ and Western blot analysis of Notch1 and Jagged1. Our results obtained from the rats treated with catalpol, positive drug and control showed that catalpol could protect rats from infarction probably by mobilization of EPCs and activation of Notch1 signaling pathway.
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篇名 Protective Effect of Catalpol on Myocardium in Rats with Isoprenaline-Induced Myocardial Infarcts via Angiogenesis through Endothelial Progenitor Cells and Notch1 Signaling Pathway
来源期刊 药理与制药(英文) 学科 医学
关键词 Myocardial Infarction Endothelial PROGENITOR Cell NOTCH1 Signaling Pathway ANGIOGENESIS CATALPOL
年,卷(期) ylyzyyw_2013,(8) 所属期刊栏目
研究方向 页码范围 619-627
页数 9页 分类号 R5
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节点文献
Myocardial
Infarction
Endothelial
PROGENITOR
Cell
NOTCH1
Signaling
Pathway
ANGIOGENESIS
CATALPOL
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研究来源
研究分支
研究去脉
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相关学者/机构
期刊影响力
药理与制药(英文)
月刊
2157-9423
武汉市江夏区汤逊湖北路38号光谷总部空间
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444
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