Evaluation of Antioxidant and Cytotoxic Capacity of <i>Croton bonplandianum</i>. Baill

• 作者: Bashir Ahmad Chaudary Muhammad Naeem Qaisar Muhammad Uzair Sajid Nawaz Hussain
• 来源期刊: 美国植物学期刊(英文)
• 学科: 医学
• 关键词: ANTIOXIDANT ACTIVITY Scavenging ACTIVITY CYTOTOXIC ACTIVITY Brine Shrimp CROTON bonplandianum
• 年，卷（期）: 2013,（9）
• 页码范围: 1709-1712
• 页数: 4页
• 分类号: R28

摘要

The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts were evaluated for their brine shrimp lethality. Methanolic extract showed cytotoxic activity in vitro with a LD50 value of 115.76 (0.0048-3.76) μg/ml. Etoposide was used as standard drug. Put together, these results confirm that Croton bonplandianum extracts possess appreciable natural antioxidant and cytotoxic potentials, thereby providing good justification for the isolation of pure bioactive compounds.