Microwave Assisted Peptide Synthesis as a New Gold Standard in Solid Phase Peptide Synthesis: Phospholamban as an Example

• 作者: Bryce Hina Gary Lorigan Ghaffari Shahrokh Mohannad Al-Saghir Philip Garber Shadi Abu-Baker Trevor Reed
• 来源期刊: 合成理论与应用(英文)
• 学科: 化学
• 关键词: SOLID-STATE PEPTIDE SYNTHESIS PHOSPHOLAMBAN MICROWAVE Assisted SYNTHESIS
• 年，卷（期）: 2014,（1）
• 页码范围: 1-4
• 页数: 4页
• 分类号: O6

摘要

In this study, we report the microwave assisted synthesis of Phospholamban protein (WT-PLB) as a new gold standard in solid phase peptide synthesis. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis. The use of microwave energy for both the coupling and deprotection steps makes the microwave peptide synthesizers the most versatile and powerful systems available. It produces high yield and fast synthesis when compared to conventional peptide synthesizers.