Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst

• 作者: Hiroyuki Miyashita Hisao Kansui Hitoshi Yoshimitsu Kazuki Watanabe Mamika Shinada Tomoko Mineno
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Indium(III) TRIFLATE Primary AMIDES NITRILES
• 年，卷（期）: 2014,（1）
• 页码范围: 1-6
• 页数: 6页
• 分类号: O6

摘要

Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.