This paper discusses some of the key aspects of human factors in anaesthesia for the improvement of patient safety.Medical errors have emerged as a serious issue in healthcare delivery.There has been new interest in human factors as a means of reducing these errors.Human factors are important contributors to critical incidents and crises in anaesthesia.It has been shown that the prevalence of human factors in anaesthesia can be as high as 83%.Cognitive thinking process and biases involved are important in understanding human factors.Errors of cognition linked with human factors lead to anaesthetic errors and crisis.Multiple errors in the cognitive thinking process,known as“Cognitive dispositions to respond”have been identified leading to errors.These errors classified into latent or active can be easily identified in the clinical vignettes of serious medical errors.Application of the knowledge on human factors and use of cognitive de-biasing strategies can avoid human errors.These strategies could involve use of checklists,strategies to cope with stress and fatigue and the use of standard operating procedures.A safety culture and health care model designed to promote patient safety can compliment this further.Incorporation of these strategies strengthens the defence layers against the“Swiss Cheese”models,which exist in the health care industry.