Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms

• 作者: Kazuyuki Ogawa Kinya Nagata Masayuki Nagasawa Norio Shimizu
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: GRANULYSIN Saposin-like protein family Natural KILLER cell CYTOTOXIC T LYMPHOCYTE
• 年，卷（期）: 2014,（4）
• 页码范围: 128-137
• 页数: 10页
• 分类号: R

摘要

Granulysin is a cytotoxic granular protein that was identified from human T cells by using the gene subtraction method in 1987.Based on its amino acid homology,granulysin belongs to the saposin-like protein family.The bioactive 9-kDa form of granulysin is processed from the 15-kDa pro-product in the cytoplasmic granules.It is expressed in CD8-positiveαβT cells 5 d after mitogenic stimulation and constitutively in natural killer(NK)cells andγδT cells,although regulation of its expression has not yet been precisely determined.The 9-kDa granulysin form has anti-microbial activity against microorganisms such as bacteria,fungi,mycobacteria and parasites,as well as tumoricidal activity against some tumors at 1-10μmol/L concentrations.Granulysin is secreted in both Ca-dependent and independent manners.In sera,only the 15-kDa form is detectable and is expected to be a biomarker for immune potency,acute viral infection,anti-tumor immune reaction,acute graft vs host disease,and NK cell associated neoplasm.