Systems biology unravels interferon responses to respiratory virus infections

• 作者: Andrea L Kroeker Kevin M Coombs
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: RESPIRATORY virus INTERFERON Systems biology Proteomics GENOMICS INNATE immunity
• 年，卷（期）: 2014,（1）
• 页码范围: 12-25
• 页数: 14页
• 分类号: R373

摘要

Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. In recent years there has been an explosion of information on virusinduced alterations of the host immune response that have resulted from data-rich omics technologies. Unravelling how these systems interact and determining the overall outcome of the host response to viral infection will play an important role in future treatment and vaccine development. In this review we focus primarily on the interferon pathway and its regulation as well as mechanisms by which respiratory RNA viruses interfere with its signalling capacity.