Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia

• 作者: Domenico Bonamonte Giampaolo Arcamone Michele Pascone Nicola Santoro Teresa Perillo
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: CALCINOSIS Cutis Treatment IMMUNOCOMPROMISED LEUKEMIA
• 年，卷（期）: 2014,（1）
• 页码范围: 13-17
• 页数: 5页
• 分类号: R73

摘要

Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calcinosis cutis is benign in immunocompetent children. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia (ALL) who developed severe calcinosis cutis in the left humerus after extravasation of calcium gluconate during the treatment for the tumor-lysissyndrome-related hypocalcaemia. Surgical debridement and local wound care were not successful, and so a temporary suspension of chemotherapy was necessary to achieve complete healing of the lesion. Notwithstanding this complication, her ALL is in complete hematological remission after 8 months from the diagnosis. No functional or sensitive impairment due to the cutis has persisted.