Periodontitis and cardiovascular disease have a complex etiology and genetics and share some common risk factors(i.e.,smoking,age,diabetes,etc.).In recent years,the relationship between periodontal disease and cardiovascular disease has been investigated extensively.This research mostly focused on the fact that periodontitis is an independent risk factor for cardiovascular disease.Our aim in this article is to investigate the etiological relationship between periodontal disease and cardiovascular disease and the mechanisms involved in this association.According to the current literature,it is concluded that there is a strong relationship between these chronic disorders.