Wound healing reaction:A switch from gestation to senescence

• 作者: Carlos Gilsanz Jaime Arias Jose-Ignacio Arias Luis-Alfonso Arraez-Aybar Maria-Angeles Aller
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: WOUND HEALING Repair EMBRYONIC mechanisms Vitelline Amniotic
• 年，卷（期）: 2014,（2）
• 页码范围: 16-26
• 页数: 11页
• 分类号: R

摘要

The repair of wounded tissue during postnatal life could be associated with the upregulation of some functions characteristic of the initial phases of embryonic development.The focusing of these recapitulated systemic functions in the interstitial space of the injured tissue is established through a heterogeneous endothelial barrier which has excretory-secretory abilities which in turn,would induce a gastrulation-like process.The repair of adult tissues using upregulated embryonic mechanisms could explain the universality of the inflammatory response against injury,regardless of its etiology.However,the early activation after the injury of embryonic mechanisms does not always guarantee tissue regeneration since their long-term execution is mediated by the host organism.