Unusual cytogenetic abnormalities associated with Philadelphia chromosome

• 作者: Anil Handoo Dharma Choudhary Nitin Gupta Sanjeev Kumar Sharma
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: PHILADELPHIA CHROMOSOME CYTOGENETIC ABNORMALITIES
• 年，卷（期）: 2014,（3）
• 页码范围: 115-117
• 页数: 3页
• 分类号: R

摘要

Cytogenetic abnormalities are the hallmark of leukemias.We report here two cases of unusual cytogenetic abnormalities associated with Philadelphia chromosome,one with mixed phenotypic acute leukemia showing monosomy 7 and t(9;22)(q34;q11.2)and the other with chronic myeloid leukemia and additional translocation involving chromosomes 10 and 13.Both patients achieved complete remission following imatinib based treatment.