A comprehensive meta-analysis of the association between three <i>IL</i>1B polymorphisms and rheumatoid arthritis

• 作者: Cheng Chen Dongjun Dai Guanghui Pan Huadan Ye Leiting Xu Limin Xu Lingling Tang Lingyan Wang Meng Ye Ping Ru Qingqing Ma Shiwei Duan Wenjing Yu Xingyu Zhou Xuting Xu Yi Jiang
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: RHEUMATOID ARTHRITIS META-ANALYSIS Polymorphism IL1B-511 Dominant Model
• 年，卷（期）: 2014,（2）
• 页码范围: 108-116
• 页数: 9页
• 分类号: R73

摘要

Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627;IL1B-511: rs16944;IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA.