Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1<i>H</i>-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate

• 作者: Daihua Hu Dehua Zhang Guanghui Tian Hongguang Ge Xiaoyan Cao Yang Liu
• 来源期刊: 结晶过程及技术期刊(英文)
• 学科: 化学
• 关键词: ANTICANCER NUCLEOSIDES INTERMEDIATE Triazole NUCLEOSIDES
• 年，卷（期）: 2014,（3）
• 页码范围: 140-144
• 页数: 5页
• 分类号: O6

摘要

An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.