An Efficient Synthesis of 2,3-Diaminoacid Derivatives Using Phosphine Catalyst

• 作者: Daisuke Harada Hiroaki Kishimoto Isao Furukawa Nahoko Sugioka Tetsuo Ohta Yohei Oe Yukio Sato
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Addition ALKYNES AMINO ACIDS Catalysis MULTI-COMPONENT Reaction
• 年，卷（期）: yjhxgjqkyw_2014,（3）
• 页码范围: 189-194
• 页数: 6页
• 分类号: O6

摘要

Ethyl 2,3-diphthalimidoylpropanoate was effectively synthesized from ethyl propynoate with two equivalents of phthalimide catalyzed by triphenylphosphine in good yield. The choice of reaction media was important for selective synthesis of the desired 2,3-diaminocarboxylic acid derivatives. The reaction is considered to occur through a zwitterionic intermediate derived from the reaction of the α,β-unsaturated ester with triphenylphosphine.