Glioblastoma 干细胞: 分子的特征和治疗学的含意

• 作者: Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: GLIOBLASTOMA GLIOBLASTOMA STEM cells Selfrenewal DIFFERENTIATION Molecular MARKERS Therapy resistance
• 年，卷（期）: 2014,（2）
• 页码范围: 230-238
• 页数: 9页
• 分类号: R457.7

摘要

Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies.