Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer

• 作者: Arlen M Arlen P Coppa G Crawford J Wang X Saric O Dubeykovskiy A Molmenti E
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Colorectal 癌症 Monoclonal 抗体 IMMUNOHISTOCHEMISTRY 抗体依赖房间 cytotoxicity 肿瘤联系了抗原
• 年，卷（期）: 2014,（6）
• 页码范围: 170-176
• 页数: 7页
• 分类号: R

摘要

In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeu-tic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired im-provements that have been sought after. Adjuvant ther-apy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demon-strated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific mono-clonals targeting colorectal cancer are employed diagnos-tically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted.