MicroRNA regulation network in colorectal cancer metastasis

• 作者: Jiao-Jiao Zhou Lei Zheng Li-Feng Sun Shu Zheng
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: MICRORNAS COLORECTAL NEOPLASMS NEOPLASM METASTASIS
• 年，卷（期）: 2014,（3）
• 页码范围: 301-307
• 页数: 7页
• 分类号: R735.34

摘要

Colorectal cancer is the third most common cancer worldwide. Metastasis is a major cause of colorectal cancer-related death. Mechanisms of metastasis remain largely obscure. MicroRNA is one of the most important epigenetic regulators by targeting mRNAs posttranscriptionally. Accumulated evidence has supported its significant role in the metastasis of colorectal cancer, including epithelial-mesenchymal transition and angiogenesis. Dissecting microRNAome potentially identifies specific microRNAs as biomarkers of colorectal cancer metastasis. Better understanding of the complex network of microRNAs in colorectal cancer metastasis provide new insights in the biological process of metastasis and in the potential targets for colorectal cancer therapies and for diagnosis of recurrent and metastatic colorectal cancer.