Developed tools of Remote Sensing and Geographic Information System are rapidly spread in recent years in order to manage natural resources and to monitor environmental changes. This research aims to study the spatial behavior of the Dead Sea through time. To achieve this aim, time series analysis has been performed to track this behavior. For this purpose, fifteen satellite imageries are collected from 1972 to 2013 in addition to 2011-ASTGTM-DEM. Then, the satellite imageries are radiometrically and atmospherically corrected. Geographic Information system and Remote Sensing techniques are used for the spatio-temporal analysis in order to detect changes in the Dead Sea area, shape, water level, and volume. The study shows that the Dead Sea shrinks by 2.9 km2/year while the water level decreases by 0.65 m/year. Consequently, the volume changes by –0.42 km3/year. The study has also concluded that the direction of this shrinkage is from the north, northwest and from the south direction of the northern part due to the nature of the bathymetric slopes. In contrast, no shrinkage is detected from the east direction due to the same reason since the bathymetric slope is so sharp. The use of the Dead Sea water for industrial purposes by both Israel and Jordan is one of the essential factors that affect the area of the Dead Sea. The intensive human water consumption from the Jordan and Yarmouk Rivers for other usages is another main reason of this shrinkage in the area as well.