White matter abnormalities: Insights into the pathophysiology of major affective disorders

• 作者: Amore M Girardi P Gonda X Rihmer Z Serafini G
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 白事 hyperintensities 主要感情方面的混乱 自杀行为 NEUROIMAGING 结果
• 年，卷（期）: 2014,（6）
• 页码范围: 223-229
• 页数: 7页
• 分类号: R

摘要

The presence of white matter hyperintensities(WMHs) has been commonly associated with poor outcome in subjects with major affective disorders. Unfortunately, WMHs may be frequently confounded by the use of psychoactive medications and duration of illness. Al-though findings from the current literature are quite conflicting, we proposed that subjects with WMHs may be at higher suicidal risk when compared to other sub-groups without. Based on the Fazekas modified scale, the severity of WMHs may serve as a trait marker of disease. Interestingly, the presence of WMHs may rep-resent a neurobiological marker between the underlying vulnerability and clinical presentation of major affective disorders.