FoxO3a and disease progression

• 作者: Polla Hergert Richard Seonghun Nho
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 生物学
• 关键词: FORKHEAD BOX O Cell PROLIFERATION APOPTOSIS Stress AGING
• 年，卷（期）: 2014,（3）
• 页码范围: 346-354
• 页数: 9页
• 分类号: Q789

摘要

The Forkhead box O(FoxO) family has recently been highlighted as an important transcriptional regulator of crucial proteins associated with the many diverse functions of cells. So far, FoxO1, FoxO3 a, FoxO4 and FoxO6 proteins have been identified in humans. Although each FoxO family member has its own role, unlike the other FoxO families, FoxO3 a has been extensively studied because of its rather unique and pivotal regulation of cell proliferation, apoptosis, metabolism, stress management and longevity. FoxO3 a alteration is closely linked to the progression of several types of cancers, fibrosis and other types of diseases. In this review, we will examine the function of FoxO3 a in disease progression and also explore FoxO3a’s regulatory mechanisms. We will also discuss FoxO3 a as a potential target for the treatment of several types of disease.