Sustained attention in psychosis: Neuroimaging findings

• 作者: De Berardis D Di Giannantonio M Gambi F Lorusso M Salerno RM Sepede G Spano MC
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 持续注意 感情方面的精神病 非感情方面的精神病 精神分裂症 双极的混乱 功能的磁性的回声成像 INSULA
• 年，卷（期）: 2014,（6）
• 页码范围: 261-273
• 页数: 13页
• 分类号: R

摘要

To provide a systematic review of scientific literatureon functional magnetic resonance imaging(fMRI) stud-ies on sustained attention in psychosis. We searchedPubMed to identify fMRI studies pertaining sustainedattention in both affective and non-affective psycho-sis. Only studies conducted on adult patients using asustained attention task during fMRI scanning wereincluded in the final review. The search was conductedon September 10 th, 2013. 15 fMRI studies met our in-clusion criteria: 12 studies were focused on Schizophre-nia and 3 on Bipolar Disorder Type Ⅰ(BDI). Only halfof the Schizophrenia studies and two of the BDI stud-ies reported behavioral abnormalities, but all of themevidenced significant functional differences in brain re-gions related to the sustained attention system. Alteredfunctioning of the insula was found in both Schizophre-nia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlight-ing differences and similarities between Schizophrenia and BDI.