Anti-Colorectal Cancer Chemotherapy-Induced Diarrhoea: Current Treatments and Side-Effects

• 作者: Joel C. Bornstein Kulmira Nurgali Rachel M. McQuade
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: Oxaliplatin IRINOTECAN 5-Fluorouracil Cisplatin CARBOPLATIN CHEMOTHERAPY Colorectal Cancer Chemotherapy-Induced DIARRHOEA
• 年，卷（期）: 2014,（7）
• 页码范围: 393-406
• 页数: 14页
• 分类号: R73

摘要

Chemotherapy-induced diarrhoea (CID) is a common side-effect experienced by patients being treated with a variety of antineoplastic agents. Approximately 80% of patients undergoing chemotherapeutic treatment for colorectal and other gastrointestinal cancers present with CID;moreover, about 5% of early deaths associated with combination anti-cancer chemotherapy are due to CID. Chronic post-treatment diarrhoea amongst cancer survivors can persist for more than 10 years greatly effecting long-term quality of life. Gastrointestinal toxicities such as diarrhoea and vomiting are amongst the primary contributors to dose reductions and delays throughout anti-cancer treatment, presenting a significant hurdle in clinical management of anti-cancer regimes and often result in sub-optimum treatment. However, little is known about pathophysiological mechanisms underlying CID. This work provides a review of chemotherapy-induced diarrhoea, current management guidelines, and shortcomings of current treatments as well as emerging and already existing anti-diarrhoeal treatments potentially suitable for CID.