Once the disaster occurred, a huge amount of grain supply is needed from disaster area. Because of the short shelf life, grain is very strict with reserve environment and needed to rotate on a regular basis in the process of reserves. Considering the limitations of existing related research, this paper presented a facility location model for grain emergency network that incorporates inventory factors and rotation mechanism, and then designed genetic algorithm based on Matlab to solve the model. Finally we verified the feasibility and effectiveness of the algorithm by computational examples and presented the directions for future work.