Tamoxifen Injection induce transient myocardiac dysfunction in mice

• 作者: Bin Yu Sheng Liu Yan Yan Wang
• 来源期刊: 生物技术世界
• 学科: 医学
• 关键词: TAMOXIFEN CARDIOLOGY ECHO
• 年，卷（期）: swjssj_2014,（3）
• 页码范围: 99-101
• 页数: 3页
• 分类号: R965

摘要

Tamoxifen inducible cre-loxp system has been employed as a very powerful tool for cardiology research in mice. It enables researchers to control their interested gene expression in tight control in terms of tissue specification and time specification. Here, we reported that in the absence of loxp transgenes,tamoxifen injection can lead to myocardiac dysfunction 3 days after drug administration but cardiac function start recover from 2 days later.