Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children

• 作者: Eman R. Youness Nadia A. Mohammed Omar M. E. Abdel-Salam Walaa A. Abu Elhamed
• 来源期刊: 分子和综合生理学期刊(英文)
• 学科: 医学
• 关键词: AUTISM Spectrum DISORDER OXIDATIVE Stress Redox-Sensing TRANSCRIPTION Factor
• 年，卷（期）: 2015,（1）
• 页码范围: 18-27
• 页数: 10页
• 分类号: R73

摘要

The aim of the present study was to investigate the status of oxidative stress in the serum of children affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched with 20 typically developing children. Changes in the levels of the redox-sensing transcription factor nuclear factor-kappa B (NF-κB) was measured in serum of autistic children and controls. Other oxidative stress biomarkers such as malondialdehyde, reduced glutathione, total antioxidant capacity, catalase activity, and paraoxonase 1 activity were determined in serum as well. Significant increase was observed in serum NF-κB of autistic children compared to that in controls (by 138.6%). There was also marked increase in malondialdehyde level by 87.3% in autistic patients. Meanwhile, there were significant decreases in reduced glutathione (by 24%), catalase activity (by 40.8%), paraoxonase 1 activity (by 36.6%), and total antioxidant capacity (by 36.5%) compared to the control group. These data clearly demonstrate increased oxidative stress in serum of autistic children and suggest that the NF-κB signaling pathway is activated in autism, possibly due to increased oxidative burden.