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摘要:
Given the broad application of aspirin as antiplatelet drug, availability of standardized methodology to assess potential interaction with any co-medication on platelet aggregation is desired. We characterized the effect of aspirin (ASA) therapy on collagen-induced platelet aggregation in whole blood to define such methodology. Collagen-induced platelet whole blood aggregation was assessed in 6 healthy male volunteers on 2 occasions (Day 1, Day 7) using the Chronolog aggregometer. From Day 2 up to Day 7, subjects received a daily oral dose of 75 mg ASA. The relationship between collagen dose and platelet aggregation response was assessed. On Day 1, maximal aggregation was observed at 1 μg/mL collagen (15.3 ± 4.6 Ω) and higher. Reproducible results were obtained without any indication of intra-subject fluctuations. ASA treatment decreased maximal aggregation by 80% and 38% at 0.5 and 2.0 μg/mL collagen, respectively. Power calculations were performed based on the observed intra-subject variability and demonstrated minimal sample sizes of 9 - 11 subjects for future cross-over ASA-drug interaction studies exploring effects on platelet aggregation, which demonstrates that the proposed collagen-induced ex vivo whole blood platelet aggregation is a feasible methodology to evaluate ASA-drug interactions in healthy volunteers.
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篇名 Evaluation of the Effect of Aspirin on Platelet Aggregation: Methodological Recommendations for Aspirin-Drug Interaction Studies
来源期刊 生物医学工程(英文) 学科 医学
关键词 PLATELET Aggregation Impedance AGGREGOMETRY WHOLE Blood COLLAGEN ASPIRIN Interaction
年,卷(期) swyxgcyw_2015,(1) 所属期刊栏目
研究方向 页码范围 40-45
页数 6页 分类号 R73
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研究主题发展历程
节点文献
PLATELET
Aggregation
Impedance
AGGREGOMETRY
WHOLE
Blood
COLLAGEN
ASPIRIN
Interaction
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
生物医学工程(英文)
月刊
1937-6871
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
252
总下载数(次)
1
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