Relevance of MICA Alleles Matching Rate and Posttransplant Rejection in Clinical LRD Organ Transplantations

• 作者: Boquan Jin Chunsheng Xu Gang Ji Guanglong Dong Liang He Weizhong Wang Zhang Zhang
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: MHC HLA MHC Class I RELATED CHAIN A (MICA) POLYMERASE CHAIN Reaction (PCR) Living RELATED Donor Transplantation (LRD)
• 年，卷（期）: 2015,（1）
• 页码范围: 33-43
• 页数: 11页
• 分类号: R73

摘要

Objective: Recipients usually undergo posttransplant rejection in HLA-identical transplantations. Recent studies have shown that MHC class I related chain A (MICA) has been found to be associated with allograft survival. The goal of this study is to investigate the correlation between matching rate of MICA alleles and posttransplant rejection in clinical living related donor transplantation (LRD) organ transplantations. Methods: Twenty pairs of blood samples were detected for HLA/MICA matching through polymerase chain reaction with sequence specific primers and for anti-MICA Abs using Luminex. At the same time, pathologic biopsies of all recipients were diagnosed and classified into different levels by the unified standard. Univariate Spearman’s analysis was established. Log-Rank analysis was performed twice, and Kaplan-Meier survival curves were generated to assess the relationship between MICA matching rates and posttransplant rejection in living-related donor transplantations. Results-The result showed that HLA matching of all recipients and donors were identical, whereas MICA matching was not. There was statistical difference between pathological classification and survival (P