Column frame of folk dwellings with slope roof in Tibetan regions of Yunnan Province was studied. Through field investigation and surveying, column frame timber, main components and construction techniques were introduced. The research showed that column frame of slope-roof dwelling in Tibetan regions of Yunnan is a regional construction technique using timber as the major materials, tenon-and-mortise work as the major connection, characterized by excellent structural expandability, and shock resistance, but it has no quantitative technical support. Scientific and systemic study is needed to improve safeness and livability of local dwellings.