Context: Patellofemoral Pain (PFPS) accounts for up to 25% of knee injuries in sports medicine clinics, with up to 91% of symptoms unresolved after conservative treatment at 5 years. The variability of response to treatment reflects its multi-factorial biomechanical etiologies. Bracing has been utilized to modify patellofemoral kinematics, generally by increasing patellofemoral contact area. The DJO Reaction orthosis is unique in its shock-absorbing elastomeric design, which is created to dissipate peak stress and enhance patellar tracking. Objective: To assess whether the DJO Reaction Brace reduces pain and improves functional outcomes in patients with chronic PFPS. Design: Cohort Series. Setting: Academic Sports Medicine Clinic. Patients: Twenty-two individuals between 18 and 40 years old with chronic patellofemoral pain have failed conservative treatment. Intervention: DJO Reaction Brace. Main Outcome Measures: Kujala Anterior Knee Pain Scale, Knee Injury and Osteoarthritis Outcome Score. Results: Seven males and 10 females with an age range of 19 - 39 years old complete the study. At an average follow-up time of 55 days, the Kujala score significantly improves by 9.8%, and KOOS Scores increase by the following statistically significant amounts: symptom 3.2%, pain 10.7%, sports and recreation 12.9%, quality of life 20.2%. Conclusion: The DJO Reaction orthosis reduces knee pain, increases function, and enhances quality of life with individuals with PFPS and is effective in the conservative care of patellofemoral pain syndrome.