Are there new approaches for diagnosis,therapy guidance and outcome prediction of sepsis?

• 作者: Benedikt H Siegler Christoph Lichtenstern Dubravka Kojic Florian Uhle Markus A Weigand Peter P Nawroth Stefan Hofer Thorsten Brenner
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: CLINICAL DECISION-MAKING Biomarkers EARLY prediction SEPSIS and MORTALITY
• 年，卷（期）: 2015,（2）
• 页码范围: 50-63
• 页数: 14页
• 分类号: R

摘要

one of the most frequent causes of death in critically ill patients.It is the most common condition with high mortality in intensive care units.The complexity of the septic syndrome comprises immunological aspects-i.e.,sepsis induced immunosuppression-but is not restricted to this fact in modern concepts.So far,exact mechanisms and variables determining outcome and mortality stay unclear.Since there is no typical risk profile,early diagnosis and risk stratification remain difficult,which hinders rapid and effective treatment initiation.Due to the heterogeneous nature of sepsis,potential therapy options should be adapted to the individual.Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making.Beyond the acute phase proteins,a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation.So far,clinical decision just based on biomarker assessment is not yet feasible.However,biomarkers should be considered as a complementary approach.