Molecular basis of cleft palates in mice

• 作者: Hiromi Yanagisawa Masataka Nakamura Noriko Funato
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Tbx1 SUBMUCOSAL CLEFT PALATE Incomplete CLEFT PALATE Palatal SHELF Palatogenesis KNOCKOUT MICE
• 年，卷（期）: 2015,（3）
• 页码范围: 121-138
• 页数: 18页
• 分类号: R782.2

摘要

Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis.