Contribution of miRNAs to ion-channel remodelling in atrial fibrillation

• 作者: Amelia E Aránega Diego Franco José Manuel Vilches
• 来源期刊: 世界高血压杂志
• 学科: 医学
• 关键词: ATRIAL FIBRILLATION MicroRNA Ion CHANNELS Electrical REMODELLING
• 年，卷（期）: 2015,（1）
• 页码范围: 6-13
• 页数: 8页
• 分类号: R

摘要

Atrial fibrillation(AF)is the most commonly encountered clinical arrhythmia associated with pronounced mortality and morbidity,which are related to palpitations,fainting,congestive heart failure,and stroke.Prolonged episodes of AF promote AF persistence mainly due to electrical remodelling that alters ion-channel expression and/or function.MicroRNAs(miRNAs),a new class of noncoding mRNAs of around 22 nucleotides in length,have recently emerged as one of the key players in the geneexpression regulatory networks.The potential roles of miRNAs in controlling AF have recently been investigated.Several recent studies have provided promising results for a better understanding of the molecular mechanisms of AF.In this review,we summarize the mechanism of miRNAs as regulators of ion-channel gene expression and their role in causing AF through electrical remodelling.