Antidiabetic Effects of Omega-3 Polyunsaturated Fatty Acids: From Mechanism to Therapeutic Possibilities

• 作者: Mariko Takeda-Morishita Noriyasu Kamei Yuko Iwase
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: Omega-3 Polyunsaturated FATTY ACIDS Diabetes INSULIN SECRETION Docosahexaenoic Acid
• 年，卷（期）: 2015,（3）
• 页码范围: 190-200
• 页数: 11页
• 分类号: R5

摘要

Diabetes mellitus (DM) is chronic disease characterized by hyperglycemia and insulin resistance caused by dysfunction of pancreatic β cells. Over the past few decades, epidemiological studies have suggested that dietary long-chain polyunsaturated fatty acids such as docosahexaenoic acid and eicosapentaenoic acid decrease the risk of metabolic diseases including DM. The mechanisms underlying the therapeutic efficacy of dietary long-chain polyunsaturated fatty acids in treating DM have been partly revealed. In this review, the authors describe the antidiabetic effects of long-chain polyunsaturated fatty acids and also discuss their possibilities as therapeutics for DM in the light of recent findings.