Current developments in pharmacological therapeutics for chronic constipation

• 作者: Chunhuan Jiang Hongbin Sun Qinglong Xu Xiaoan Wen
• 来源期刊: 药学学报:英文版
• 学科: 医学
• 关键词: Chronic constipation Prokinetic agent 5-HT1 receptor Prosecretory agent
• 年，卷（期）: 2015,（4）
• 页码范围: 300-309
• 页数: 10页
• 分类号: R574.62
• 语种: 中文

摘要

Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride,the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field.