SIRT1 and stem cells： In the forefront with cardiovasculardisease, neurodegeneration and cancer

• 作者: Kenneth Maiese
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: FoxO Mechanistic of rapamycin Apoptosis Autophagy Cardiovascular CYSTEINE-RICH protein 61 connective tissue growth factor and nephroblastomaover-expressed gene NEURODEGENERATION Progenitorstem cells SIRT1 CANCER
• 年，卷（期）: 2015,（2）
• 页码范围: 235-242
• 页数: 8页
• 分类号: R

摘要

Cardiovascular disease, nervous system disorders, andcancer in association with other diseases such as diabetesmellitus result in greater than sixty percent of the globalannual deaths. These noncommunicable diseases alsoaffect at least one-third of the population in low andmiddle-income countries and lead to hypertension,elevated cholesterol, malignancy, and neurodegenerativedisorders such as Alzheimer＇s disease and stroke. Withthe climbing lifespan of the world＇s population, increasedprevalence of these disorders is expected requiringthe development of new therapeutic strategies againstthese disabling disease entities. Targeting stem cellproliferation for cardiac disease, vascular disorders,cancer, and neurodegenerative disorders is receivinggreat enthusiasm, especially those that focus uponSIRT1, a mammalian homologue of the yeast silentinformation regulator-2. Modulation of the cellular activityof SIRT1 can involve oversight by nicotinamide/nicotinicacid mononucleotide adenylyltransferase, mammalianforkhead transcription factors, mechanistic of rapamycinpathways, and cysteine-rich protein 61, connective tissuegrowth factor, and nephroblastoma over-expressedgene family members that can impact cytoprotectiveoutcomes. Ultimately, the ability of SIRT1 to controlthe programmed cell death pathways of apoptosis andautophagy can determine not only cardiac, vascular, andneuronal stem cell development and longevity, but alsothe onset of tumorigenesis and the resistance againstchemotherapy. SIRT1 therefore has a critical role andholds exciting prospects for new therapeutic strategiesthat can offer reparative processes for cardiac, vascular,and nervous system degenerative disorders as well astargeted control of aberrant cell growth during cancer.