A Hypothesis Concerning the Effect of Schedule on the Pattern of 5-Fluorouracil Toxicity

• 作者: Arthur J. Weiss
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: EFFECT of Scheduling upon Selective ORGAN 5-FLUOROURACIL TOXICITY Computer Modeling
• 年，卷（期）: azzlyw_2015,（3）
• 页码范围: 251-256
• 页数: 6页
• 分类号: R73

摘要

The significant effect that scheduling has upon the severity and types of drug toxicity has been known for many years. Evidence is available demonstrating that the schedule chosen will substantially effect the relative distribution of drug to various target organs. It has been shown that a likely cause for this with doxorubicin is that the efficiency of the various enzyme complexes responsible for disposing of the drug can be affected by scheduling. We believe a similar process can explain the marked effect that scheduling has on the pattern of 5-fluorouracil toxicity and present both clinical and computer data to illustrate this.